A highly diverse team imagining the undiscovered

RENAL RESEARCH INSTITUTE

Transforming
patient care
through data-driven
innovation

ABOUT THE RENAL RESEARCH INSTITUTE

The heart of RRI’s capacity for innovation is our ability to examine complex problems through multiple lenses.

The Renal Research Institute (RRI) is an internationally recognized incubator of ideas, treatment processes, and technologies to improve the lives of kidney patients. RRI’s leadership in data analytics, computational biomedicine and AI, as well as our access to a large patient population, accelerates the pace of scientific discoveries and their translation into applied medicine. Our team includes some of the brightest minds from around the world, who, along with their disciplinary expertise, bring a deep understanding of global healthcare issues and challenges.

 

Our Research

We operate at the intersection of clinical data, machine data, and real-world practice, with access to a large patient population and one of the world's largest and richest renal datasets. Our deep connection to the scientific community and to med-tech innovators gives us the rare ability to translate insight into action—quickly, precisely, and meaningfully.

 

Latest Research & News

Latest Research

  • Richard J Gray, Sheetal Chaudhuri, Hao Han, John Larkin, Murat Sor, Gregg M Miller

    Background Ports have traditionally been inserted in hospitalized inpatients; however, there has been an increasing transition to outpatient placement by interventionalists in hospital imaging suites. To our knowledge, port implantation in nonhospital settings has not been reported in peer-reviewed literature. Here, we report our experience with port placement in freestanding outpatient vascular centers. Methodology The electronic medical record for 47 centers was retrospectively searched to identify port placements between January 1, 2012, and December 31, 2018. Data included indications, platelet inhibitor/anticoagulants, American Society of Anesthesiologists (ASA) classification, port type, site, tip position, peri-procedure medications, procedure time, and pain scores. Complications were determined by phone calls at 48-72 hours. Results No short-term malfunctions were reported. In total, 5,890 ports were placed for chemotherapy (n = 5,531), IV therapy (n = 77), antibiotics (n = 74), hyperalimentation (n = 19), phlebotomy (n = 7), medications (n = 4), miscellaneous (n = 74), and unknown (n = 104). Regarding ASA classifications, 1% (n = 65) were categorized as Class I, 20% (n = 1,203) as Class II, 78% (n = 4,592) as Class III, and 0.5% (n = 30) as Class IV. Overall, 3,712 were single-lumen power ports, 341 dual-lumen, 19 unknown, 7 arm, 1 other, and 1,810 were unspecified. There were 5,855 chest, 19 arm, 1 thigh, and 15 unspecified ports. Tips were positioned in the superior vena cava (n = 1,582), superior vena cava-right atrium (n = 497), right atrium (n = 272), inferior vena cava (n = 2), inferior vena cava-right atrium (n = 1), or not specified (n = 3,536). The mean procedure time was 29 minutes (range = 6-137). The mean peak pain score was 0.86 (range = 0-10). Complications (n = 33) included 16 emergency/hospital admissions <24 hours for port-site bleeding (2), infection (1), pneumothorax (1), EKG changes (1), respiratory symptoms (3), tachycardia (2), unconfirmed infection (1), fall (1), chest pain (1), syncope (1), pain (1), or other (1). Furthermore, 17 Other complications included unrelated/unconfirmed infection (4), death <30 days (1), shortness of breath (1), infection (1), reversal agent (1), hypoglycemia (1), fall (1), and other (7). No leaks were reported. Conclusions According to the study findings, port placement in outpatient centers appears to be safe and provides short-term effectiveness.

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Education

LATEST EPISODE

Aging with Dignity: Grief, Depression, and the Human Side of Kidney Care

January 5, 2025

Aging, end-of-life planning, and depression are topics many people avoid, but for patients living with kidney disease, these realities are part of everyday life. In this episode of Frontiers in Kidney Medicine and Biointelligence, host Len Usvyat speaks with Felicia Speed, PhD, LMSW, Vice President of Social Work Services at Fresenius Medical Care, about the emotional and psychological challenges patients face as their health declines.

With more than 26 years of experience in nephrology social work, Felicia discusses: 

• How grief differs from depression, and why the distinction matters 
• What aging patients fear most — and what gives them meaning 
• The emotional weight carried by caregivers 
• How social workers help patients reimagine their future 
• Why listening is often more powerful than any intervention 
• The importance of capturing stories, legacy, and identity at end of life 
• The need for research that centers patient narratives 

She also shares moving patient stories that shed light on resilience, legacy, and the human connections formed in dialysis facilities.

If you work in kidney care, or care for someone navigating chronic illnesses, this conversation offers a compassionate and deeply insightful perspective.