Current opinion in nephrology and hypertension
November 7, 2025
Artificial intelligence in kidney disease and dialysis: from data mining to clinical impact
Luca Neri, Hanjie Zhang, Len A Usvyat
PURPOSE OF REVIEWArtificial intelligence (AI) and machine learning (ML) are rapidly transforming healthcare, but their adoption in nephrology and dialysis remains relatively limited.SUMMARYAI in nephrology shows promise for personalized care and cost reduction, as demonstrated by tools like the Anemia Control Model. Yet, broad adoption requires rigorous validation, seamless workflow integration, regulatory clearance, and clinician trust. Future opportunities include digital twins, large language models, and multiomics integration, with AI poised to enhance both patient outcomes and system performance.RECENT FINDINGSThis review highlights key applications of AI in kidney disease, including prognostic modeling, imaging, personalized anemia and fluid management, patient engagement, and research acceleration. While numerous studies demonstrate improved prediction accuracy and clinical insights, translation into routine practice is rare. Examples such as the Anemia Control Model (ACM) demonstrate that AI can simultaneously improve clinical outcomes and reduce costs, though widespread adoption will require rigorous validation, seamless integration into clinical workflows, regulatory approval, and above all, clinician trust.
