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  • Alhaji Cherif, Joanna L. Willetts, Len Usvyat, Yue...

    Chronic hemodialysis is a life-sustaining therapy, delivered mostly thrice weekly in dialysis clinics. For patients on dialysis who appear to have a heightened likelihood of severe infection or death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), travel to these facilities and proximity to fellow patients and health care providers during hemodialysis may pose an...

  • Jeroen P. Kooman, Peter Stenvinkel, Paul G. Shiels...

    Patients treated with hemodialysis (HD) repeatedly undergo intradialytic low arterial oxygen saturation and low central venous oxygen saturation, reflecting an imbalance between upper body systemic oxygen supply and demand, which are associated with increased mortality. Abnormalities along the entire oxygen cascade, with impaired diffusive and convective oxygen transport, contribute to the reduced tissue oxygen supply....

  • David F. Keane, Jochen G Raimann, Hanjie Zhang, Jo...

    Intradialytic hypotension (IDH) is a common complication of hemodialysis, but there is no data about the time of onset during treatment. Here we describe the incidence of IDH throughout hemodialysis and associations of time of hypotension with clinical parameters and survival by analyzing data from 21 dialysis clinics in the United States to include 785682...

  • Pamplona G, Sullivan T, Peter Kotanko

    Broad adoption of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key to successfully fighting the spread of coronavirus disease 2019 (COVID-19). When fallen ill with COVID-19, in-center hemodialysis patients are at particularly high risk for morbidity and mortality.1 , 2 Therefore, attaining high vaccination rates in both dialysis patients and staff is of utmost importance....

  • Maggie Han, Xiaoling (Janice) Ye, Stephan Thijssen...

    Background/aims: Hepatitis B (HB) vaccination in hemodialysis patients is important as they are at a higher risk of contracting HB. However, hemodialysis patients have a lower HB seroconversion rate than their healthy counterparts. As better sleep has been associated with better seroconversion in healthy populations and early hemodialysis start has been linked to significant sleep-wake disturbances...

  • Sheetal Chaudhuri, Andrew Long, Hanjie Zhang, Cait...

    Artificial intelligence (AI) is considered as the next natural progression of traditional statistical techniques. Advances in analytical methods and infrastructure enable AI to be applied in health care. While AI applications are relatively common in fields like ophthalmology and cardiology, its use is scarcely reported in nephrology. We present the current status of AI in...

  • Gabriela Ferreira Dias, Nadja Grobe, Sabrina Rogg,...

    Red blood cells (RBC) are the most abundant cells in the blood. Despite powerful defense systems against chemical and mechanical stressors, their life span is limited to about 120 days in healthy humans and further shortened in patients with kidney failure. Changes in the cell membrane potential and cation permeability trigger a cascade of events...

  • Murilo Guedes, Roberto Pecoits-Filho, Juliana El G...

    Background Dialysis recovery time (DRT) surveys capture the perceived time after HD to return to performing regular activities. Prior studies suggest the majority of HD patients report a DRT > 2 h. However, the profiles of and modifiable dialysis practices associated with changes in DRT relative to the start of dialysis are unknown. We hypothesized hemodialysis (HD)...

  • Kidney International Reports
    Sep 09, 2020
    Bernard Canaud, Jeroen P. Kooman, Nicholas M. Selb...

    Hemodialysis has saved many lives, albeit with significant residual mortality. Although poor outcomes may reflect advanced age and comorbid conditions, hemodialysis per se may harm patients, contributing to morbidity and perhaps mortality. Systemic circulatory “stress” resulting from hemodialysis treatment schedule may act as a disease modifier, resulting in a multiorgan injury superimposed on preexistent comorbidities. New functional...

  • Mathematical Biosciences and Engineering
    Jun 23, 2020
    Alhaji Cherif, Vaibhav Maheshwari, Doris Fuertinge...

    Precise maintenance of acid-base homeostasis is fundamental for optimal functioning of physiological and cellular processes. The presence of an acid-base disturbance can affect clinical outcomes and is usually caused by an underlying disease. It is, therefore, important to assess the acid-base status of patients, and the extent to which various therapeutic treatments are effective in...