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Research Articles

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Displaying 10 articles
  • Clinical Microbiology and Infection
    Sep 27, 2021
    Nadja Grobe, Alhaji Cherif, Xiaoling Wang, Zijun D...

    Background: Pool-testing strategies combine samples from multiple people and test them as a group. A pool-testing approach may shorten the screening time and increase the test rate during times of limited test availability and inadequate reporting speed. Pool testing has been effectively used for a wide variety of infectious disease screening settings. Historically, it originated...

  • Ravi Thadhani, Joanna L. Willetts, Catherine Wang,...

    Background: SARS-CoV-2 can remain transiently viable on surfaces. We examined if use of shared chairs in outpatient hemodialysis associates with a risk for indirect patient-to-patient transmission of SARS-CoV-2. Methods: We used data from adults treated at 2,600 hemodialysis facilities in United States between February 1st and June 8th, 2020. We performed a retrospective case-control study...

  • Vaibhav Maheshwari, Xia Tao, Stephan Thijssen, Pet...

    Removal of protein-bound uremic toxins (PBUTs) during conventional dialysis is insufficient. PBUTs are associated with comorbidities and mortality in dialysis patients. Albumin is the primary carrier for PBUTs and only a small free fraction of PBUTs are dialyzable. In the past, we proposed a novel method where a binding competitor is infused upstream of a...

  • Sheetal Chaudhuri, Hao Han, Len Usvyat, Yue Jiao, ...

    Background: An integrated kidney disease company uses machine learning (ML) models that predict the 12-month risk of an outpatient hemodialysis (HD) patient having multiple hospitalizations to assist with directing personalized interdisciplinary interventions in a Dialysis Hospitalization Reduction Program (DHRP). We investigated the impact of risk directed interventions in the DHRP on clinic-wide hospitalization rates. Methods:...

  • Sheetal Chaudhuri, Rachel Lasky, Yue Jiao, John W....

    Introduction: The clinical impact of COVID-19 has not been established in the dialysis population. We evaluated the trajectories of clinical and laboratory parameters in hemodialysis (HD) patients. Methods: We used data from adult HD patients treated at an integrated kidney disease company who received a reverse transcription polymerase chain reaction (RT-PCR) test to investigate suspicion...

  • Sheetal Chaudhuri, Hao Han, Caitlin Monaghan, John...

    Background: Inadequate refilling from extravascular compartments during hemodialysis can lead to intradialytic symptoms, such as hypotension, nausea, vomiting, and cramping/myalgia. Relative blood volume (RBV) plays an important role in adapting the ultrafiltration rate which in turn has a positive effect on intradialytic symptoms. It has been clinically challenging to identify changes RBV in real time...

  • Ohnmar Thwin, Nadja Grobe, Leticia M Tapia Silva, ...

    There are concerns that in-center maintenance hemodialysis (HD) patients may have higher risk for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because they take 3 or more round-trips a week to dialysis centers and spend several hours during dialysis close to fellow patients and clinic staff. This concern is supported by data from...

  • Journal of the American Society of Nephrology
    Jul 19, 2021
    Xiaoling Wang, Nadja Grobe, Zahin Haq, Ohnmar Thwi...

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is primarily transmitted through aerosolized droplets.1 Patients with coronavirus disease 2019 (COVID-19) exhale SARS-CoV-2 RNA copies at a rate of 103 to 105 per minute.2 In the United States, in-center hemodialysis patients and staff are mandated to wear face masks while staying in the dialysis clinic. Previously, face mask sampling was applied...

  • Gabriela Ferreira Dias, Sara Soares Tozoni, Gabri...

    Background/aims: Chronic kidney disease is frequently accompanied by anemia, hypoxemia, and hypoxia. It has become clear that the impaired erythropoietin production and altered iron homeostasis are not the sole causes of renal anemia. Eryptosis is a process of red blood cells (RBC) death, like apoptosis of nucleated cells, characterized by Ca2+ influx and phosphatidylserine (PS)...

  • Marijke J. E. Dekker, Len Usvyat, Constantijn J. A...

    Pre-hemodialysis systolic blood pressure variability (pre-HD SBPV) has been associated with outcomes. The association of a change in pre-HD SBPV over time with outcomes, and predictors of this change, has not yet been studied. Therefore, we studied this in a cohort of 8825 incident hemodialysis (HD) patients from the European Monitoring Dialysis Outcomes Initiative database....