A highly diverse team imagining the undiscovered


A highly diverse
team imagining
the undiscovered


The heart of RRI’s capacity for innovation is our ability to examine complex problems through multiple lenses.

The Renal Research Institute (RRI) is an internationally recognized incubator of ideas, treatment processes, and technologies to improve the lives of kidney patients. RRI’s leadership in computational biomedicine and data analytics, as well as our access to a large patient population, accelerates the pace of scientific discoveries and their translation into applied medicine. Our team includes some of the brightest minds from around the world, who, along with their disciplinary expertise, bring a deep understanding of global healthcare issues and challenges.

Our Research

RRI’s pioneering leadership in computational biomedicine and data analytics drives breakthroughs, including the introduction of virtual clinical trials and smartphone-based diagnostics. Not only does our interdisciplinary approach foster wide-ranging research within the global framework of Fresenius Medical Care, it encourages collaboration with academic institutions in the United States, Asia, Europe, Latin America, and Africa.

Latest Research & News

Latest Research

  • Ariella Mermelstein, Jochen G Raimann, Yuedong Wang, Peter Kotanko, John T Daugirdas

    RESULTSIn the studied 396,358 patients, the average ultrafiltration rate in ml/h was related to postdialysis weight (W) in kg: 3W+330. Ultrafiltration rates associated with 20% or 40% higher weight-specific mortality risk were 3W+500 and 3W+630 ml/h, respectively, and were 70 ml/h higher in men than in women. Nineteen percent or 7.5% of patients exceeded ultrafiltration rates associated with a 20% or 40% higher mortality risk, respectively. Low ultrafiltration rates were associated with subsequent weight loss. Ultrafiltration rates associated with a given mortality risk were lower in high-body weight older patients and higher in patients on dialysis for more than 3 years.CONCLUSIONSUltrafiltration rates associated with various levels of higher mortality risk depend on body weight, but not in a 1:1 ratio, and are different in men versus women, in high-body weight older patients, and in high-vintage patients.BACKGROUNDWe hypothesized that the association of ultrafiltration rate with mortality in hemodialysis patients was differentially affected by weight and sex and sought to derive a sex- and weight-indexed ultrafiltration rate measure that captures the differential effects of these parameters on the association of ultrafiltration rate with mortality.METHODSData were analyzed from the US Fresenius Kidney Care (FKC) database for 1 year after patient entry into a FKC dialysis unit (baseline) and over 2 years of follow-up for patients receiving thrice-weekly in-center hemodialysis. To investigate the joint effect of baseline-year ultrafiltration rate and postdialysis weight on survival, we fit Cox proportional hazards models using bivariate tensor product spline functions and constructed contour plots of weight-specific mortality hazard ratios over the entire range of ultrafiltration rate values and postdialysis weights (W).

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Latest News

  • Renal Research Institute’s 23rd International Conference on Dialysis - Advances in Kidney Disease is rescheduled for April 20-23, 2021, but acknowledges the renal community has immediate access to the latest COVID-19 kidney care science and knowledge via online platforms. New York, March 18, 2021 – While the Renal Research Institute (RRI) has rescheduled its 23rd...

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Solutes, Scaling, Sex: are we getting the dosing of dialysis, right?

Apr 27, 2022

Join Dr. Peter Kotanko, MD, FASN, Head of Biomedical Evidence Generation and Renal Research Institute, and John Daugirdas, MD, FACP, FASN, Clinical Professor of Medicine at the University of Illinois School of Medicine at Chicago, as they discuss aspects around dialysis patient prescription.