Timothy Bunchman, MD Professor and Director Pediatric Nephrology and Transplantation Children's Hospital of Richmond at Virginia Commonwealth University Read Bio... I am an experienced clinician with a broad background in pediatric nephrology, but have cultivated my career in the subfields of critical care nephrology, nutrition and transplant management, vasculitis, and pioneered the original work in pediatric renal replacement therapy. I have served on various NIH review boards and study sections, and have been awarded prior NIH and private grants as principal investigator for clinical research in these fields. Specific to this grant application, in 2009 we published clinical research on the improvement of neonatal acute kidney injury with uric acid lowering agents. In addition, during my early basic science career my area of research was on endothelial dysfunction which relates to uric acid effects on the vascular endothelium. I lecture extensively throughout the world on these topics and have assisted the training and development of pediatric nephrology programs around the country and internationally. Specifically, I have been an invited speaker in areas of AKI, Renal Replacement Therapy and Transplantation in Russia, Egypt, Turkey, UAE, South Africa, Germany, Italy, Belgium, UK, Portugal, Chile, Brazil, Costa Rica, Mexico, Canada and the US. I am the founder and chairman of a bi-annual meeting of the International Pediatric Continuous Renal Replacement Therapy and have an active web site at www.pcrrt.com for this information and am considered the pioneer and leader in the area of pediatric continuous renal replacement therapy and critical care nephrology. I have successfully mentored clinicians and clinician scientists, and am a reviewer for greater than 30 separate medical journals, have authored greater than 140 manuscripts and greater than 40 book chapters. My experience both clinically and through my own research enables me to serve as a clinical principal investigator and mentor on this U24 grant application. I have been an invited speaker in areas of AKI, Renal Replacement Therapy and Transplantation in Russia, Egypt, Turkey, UAE, South Africa, Germany, Italy, Belgium, UK, Portugal, Chile, Brazil, Costa Rica, Mexico, Canada and the US.